Professor William Alexander Donald
W. Alexander听Donald is a Professor & ARC Future Fellow in the School of Chemistry at 亚美棋牌 who is developing and applying analytical and mass spectrometry methodologies with an emphasis on problems in chemistry and biochemistry.
Graduate of University of California, Berkeley (Ph.D., 2010). Postdoctoral Fellow & Centenary Research Fellow, University of Melbourne (2010-2012). Lecturer, 亚美棋牌听(2013). Senior Lecturer, 亚美棋牌 (2016). Associate Professor, 亚美棋牌 (2020). ARC Future Fellowship (2020).听Scientia Associate Professor (2021). Professor (2024).
International Union of Pure and Applied Chemists Prize for Young Chemists (2011). New South Wales Fresh Science Finalist (2013). ARC Discovery Early Career Researcher Award (2013). Australian and New Zealand Society for Mass Spectrometry Michael Guilhaus Research Award (2015). RACI Physical Chemistry Division Lectureship (2016).听RACI Analytical and Environmental Chemistry Division Peter W. Alexander Medal (2016). Emerging Investigator, Analytical Methods (2015), The Analyst (2016), and The Journal of the American Society for Mass Spectrometry (2017). Australian and New Zealand Society for Mass Spectrometry Bowie Medal (2019). The Analytical Scientist 2020 Power List (2020).听ARC Future Fellowship (2020).
Vice President, Australian and New Zealand Society for Mass Spectrometry (2020-current). Past听Chair, RACI NSW Analytical and Environmental Chemistry Group (2020-current). Treasurer, Australian and New Zealand Society for Mass Spectrometry (2016-2020). Chair, RACI NSW Analytical and Environmental Chemistry Group (2017-2020). Member, ANZSMS and RACI.
- Publications
- Media
- Grants
- Awards
- Research Activities
- Engagement
- Teaching and Supervision
WA Donald,听Cracking post-translational modification codes in high molecular definition; ARC Future Fellowship; 2020-2023
AJ Trevitt, WA Donald, C Jouvet;听New laser and mass spectrometry methods for detecting protonation isomers; ARC Discovery Projects; 2020-2022
WA Donald, CT Supuran; Ultrasensitive chemical analysis of single cells by mass spectrometry; ARC Discovery Project; 2019-2021
WA Donald, CT Supuran; Rapid, Ultra-sensitive Protein Structure Elucidation by Mass Spectrometry; ARC Discovery Project; 2016-2018
Mass spectrometry is a core enabling technology that is used in many emerging and existing scientific fields.听 We are developing and applying experimental methods in mass spectrometry with an emphasis on fundamental and applied problems in chemistry and biochemistry.
Our current objectives are to:
- Significantly improve the rapid detection of organic molecules, biomarkers, and proteins with ultrahigh sensitivity by use of advanced ionization, ion mobility and tandem mass spectrometry methods
- Understand the molecular origins of cellular heterogeneity by developing novel single cell mass spectrometry methodologies
- Develop high-performance, portable ion spectrometers that operate at ambient pressure for the detection of many different chemicals nearly simultaneously
- Discover and explore the mechanisms of chemical reactions that are mediated by transition metal complexes and catalysts using ion-molecule reactions, ion fragmentation methods, and ion spectroscopy
Our research is highly interdisciplinary and we actively collaborate with other researchers in pharmacology & medicinal chemistry, protein engineering, bioinorganic chemistry, molecular biology, surface & materials chemistry, and electrical engineering.听
Selected Publications
1. Nguyen, G. T. H.; Tran, T. N.; Podgorski, M. N.; Bell, S. G.; Supuran, C. T.; Donald, W. A. Nanoscale ion emitters in native mass spectrometry for measuring ligand-protein binding affinities.听ACS Central Science, 2019, 5, 308-318.
2. Winter, D. L.; Wilkins, M. R.; Donald, W. A. Differential ion mobility-mass spectrometry for detailed analysis of the proteome.听Trends in Biotechnology, 2019, 37, 198-213.
3. Zenaidee, M. A.; Leeming, M. G.; Zhang, F.; Funston, T. T.; Donald, W. A. Highly charged protein ions: The strongest organic acids to date.听Angewandte Chemie International Edition, 2017, 56, 8522-26 ("Very Important Paper").
4. Kabir, K. M. M.; Donald, W. A. Microscale differential ion mobility spectrometry for field deployable chemical analysis.听Trends in Analytical Chemistry, 2017, 97, 399-427.
5. Dumlao, M. C.; Xiao, D.; Zhang, D.; Fletcher, J.; Donald, W. A. Effects of different waveforms on the performance of active capillary dielectric barrier discharge ionization mass spectrometry.听Journal of the American Society for Mass Spectrometry, 2017, 28, 575-78 (Cover of Emerging Investigator Issue).
6. Leeming, M. G.; Donald, W. A.; O'Hair, R. A. J. Non-targeted identification of reactive metabolite protein adducts.听Analytical Chemistry, 2017, 89, 5748-56.
7.听Dumlao, M. C.; Jeffress, L. E.; Gooding, J. J.; Donald, W. A. Solid-phase microextraction low temperature plasma mass spectrometry for the direct and rapid analysis of chemical warfare simulants in complex mixtures.听Analyst, 2016, 141, 3714-21听(Emerging Investigator Issue).
8. Leeming, M. G.; Isaac, A. P.; Pope, B. J.; Cranswick, N.; Wright, C. E.; Ziogas, J.; O'Hair, R. A. J.; Donald, W. A. High-Resolution Twin-Ion Metabolite Extraction (HiTIME) Mass Spectrometry: Nontargeted Detection of Unknown Drug Metabolites by Isotope Labeling, Liquid Chromatography Mass Spectrometry, and Automated High-Performance Computing.听Analytical Chemistry, 2015,听87, 4104-09.
9. Zenaidee, M. A.; Donald, W. A.听Electron capture dissociation of extremely supercharged protein ions formed by electrospray ionisation.听Analytical Methods, 2015,听7, 7132 (Emerging Investigator Issue).
10.听Teo, C. A.; Donald, W. A. Solution Additives for Supercharging Proteins Beyond the Theoretical Maximum Proton-Transfer Limit in Electrospray Ionization Mass Spectrometry.听Analytical Chemistry, 2014,听86, 4455-62.
Editorial Activities:
Book editor, Advances in ion-mobility mass spectrometry: Fundamentals, instrumentation, and applications (Comprehensive Analytical Chemistry, Vol. 83; Elsevier, 2019)
Associate Editor (Handling Editor), Journal of Enzyme Inhibition and Medicinal Chemistry听(2019-肠耻谤谤别苍迟)
Editorial Board, International Journal of Molecular Sciences听(2018-肠耻谤谤别苍迟)
Editorial Board, Expert Opinion on Therapeutic Patents听(2017-肠耻谤谤别苍迟)
Editorial Board, Journal of Enzyme Inhibition and Medicinal Chemistry听(2017-肠耻谤谤别苍迟)
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Professional Roles:
Vice president, Australian & New Zealand Society for Mass Spectrometry (2020-current)
Past chair,听Royal Australian Chemical Institute NSW Analytical and Environmental Chemistry Group (2020-current)
Treasurer, Australian & New Zealand Society for Mass Spectrometry (2016-2020)
Chair, Royal Australian Chemical Institute NSW Analytical and Environmental Chemistry Group (2017-2020)
Chair-elect, Royal Australian Chemical Institute NSW Analytical and Environmental Chemistry Group (2015-17)
Management committee, NSW Smart Sensing Network (2016-17)
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My Research Supervision
Current group
Research Fellows and Postdocs:
Dr. K. M. Mohibul Kabir (DECRA Fellow; close collaborator)
Dr. Morphy Dumlao (with National Wine and Grape Industry Centre)
Dr. Giang Nguyen
PhD Students:
Ezaz Ahmed
Susannah Brown
Hyun Eui (Peter) Lee
Diana Zhang听
Phuong (Chi) Pham
Merryn Baker听
Suhyeon (Renee) Kwon
Alireza Mashouf
Mohammad Tajiki
Xiaojing Huang听
Masters-by-Research Student:
Qinwen Liu
Honours Students:
Jack Bennett听
Olivia Rusli
Anthony Tran (with Dr Mohibul Kabir)
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Group Alumni
Postdoc, PhD and Masters:
Fon Kankaew (MSc graduate, 2020)
Liang Jiang (MSc graduate, 2020)
Giang Nguyen (PhD graduate, 2020)
Huixin Wang (PhD graduate, 2019)
Jordan Mastellone (MPhil graduate, 2019)
Muhammad A. Zenaidee (PhD graduate, 2019)
Panthipa Suwannakot (MSc graduate, 2019)
Peter Lee (MSc graduate, 2017)
Morphy Dumlao (PhD graduate, 2017)
Toby Mills (PhD graduate, 2017)
Dr. Fangtong Zhang (Postdoctoral research fellow, 2013-2015)
Honours:
Sherrie Liu (Honours student, 2019-2020)
Merryn Baker (Honours student, 2018)
Vickie Chan (Honours student, 2018)
Diana Zhang (Undergraduate student, 2016; Honours student, 2017)
Eric Foley (Undergraduate student, 2016; University medal for honours performance, 2017)
Susannah Brown (Undergraduate student, 2015; University medal for honours performance, 2016)
Chung Hong Chan (2016)
Laura Jeffress (2015)
Grace Yong (Undergraduate student, 2015; Honours student, 2015)
Edward Stephens (2015)
Sunny Xiong (2014)
Muhammad A. Zenaidee (2014)
Edward Jiang (2013)
Ann Teo (2013)
Lab Alumni (Undergraduate students)
Manatsu Nose (2020)
Monika Vesse (2020)
Sherrie Liu (2019)
Daniel Loo (2019)
Joe Harding (2018)
Denise de Meijer (2018, visiting praticum exchange student from Saxion University, Deventer, Netherlands)
Surabhi Naik (2016)
Natalie Coulton (2016)
Mohammed Al-Farsi (2015)
Toby Funston (2015)
Precilia Hermanto (2015)
MacKenzie Hagan (2014)
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My Teaching
Course Coordinator and Lecturer, Analytical Chemistry: Essential Methods (Second Year Level, Terms 1 and 3)
Lecturer, Chemistry 1A (First Year Level, Term 3)
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